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The Science of Frailty

British Geriatrics Society

Dr. Roman Romero-Ortuno (@rrorthy7) is a newly appointed Consultant Geriatrician at Addenbrooke’s Hospital, Cambridge. In this blog, he outlines the scientific underpinnings of frailty and how this emerging science will lead to greater personalisation of treatments.

Frailty is vulnerability to decompensation after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime.

Campbell & Buchner defined frailty as ‘a condition or syndrome which results from a multi-system reduction in reserve capacity to the extent that a number of physiological systems are close to, or past, the threshold of symptomatic clinical failure; and as a consequence the frail person is at increased risk of disability and death from minor external stresses’.

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